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-synuclein, and that is a key ingredient of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which happens to be an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) pressure, counsel that dysfunction from the intracellular proteinase methods, for instance ubiquitin-proteasome program or lysosomal method, which gets rid of